Dr. Høie has over the last three decades worked with medical opinion leaders at University Hospitals in Europe and the U.S. The resulting clinical studies have been documented in 32 international publcations in world renowned medical and nutritional journals. He has used this knowledge and underlying science to create a range of proven natural plant-based products, which aim to have a profoundly positive effect on the health of many worldwide.


Details of the studies are listed below.



CLINICAL PUBLICATIONS - Weight Loss

A weight management institute location
1
S. Kornstad, A. Grøndahl

Exercise, hypertension and low calorie diet. Two pilot studies using new protein-rich low calorie diet. In Norwegian Tidsskriftet Norske Lægeforeningen 1991; 111: 3627-3629.

Humana Sandvika Norway
2
L. H. Høie, D. Bruusgaard, E. Thom

Reduction in body mass and change in body composition on a very low calorie diet. International Journal of Obesity 1993; 17:17-20

University
of Oslo
Norway
3
B. L. Heitmann, J. Kondrup, M. Engelhart, J. H. Kristensen,
J. Pødenphant, L. H. Høie, V. Andersen

Changes in fat free mass in overweight patients with rheumatoid arthritis on a weight reducing regimen. A comparison of eight different body composition methods. International Journal of Obesity 1994; 18:812-819

Copenhagen Health Services + Municipal Hospital, Copenhagen Denmark
4
P. Anderson, I. Seljeflot, M. Abdeinoor, H. Arnesen, P.O. Dale,
A. Løvik, K. Birkeland

Exercise, hypertension and low calorie diet. Two pilot studies using new protein-rich low calorie diet. In Norwegian Tidsskriftet Norske Lægeforeningen 1991; 111: 3627-3629.

Humana Sandvika Norway
5
L. H. Høie, D. Bruusgaard

Compliance, clinical effects, and factors predicting weight reduction during a very low calorie diet regime.
Scand J Prim Health Care 1995; 13:13-20

University of Oslo Norway
6
S. Rössner, B. Barkeling, Å. Asp, H. Flaten, P. Fuglerud

Effects of weight loss on single meal eating behaviour in obese subjects.
International Journal of Obesity 1996; 20:287-289

Karolinska Hospital, Stockholm Sweden
7
M. Engelhart, J. Korndrup, L.H. Høie, V. Andersen,
J.H. Kristensen, B.L. Heitmann

Weight reduction in obese patients with rheumatoid arthritis, with preservation of body cell mass and improvement of physical fitness.
Clinical and Experimental Rheumatology 1996; 14:289-293

Rigshospitalet, Copenhagen Denmark
8
T. Pekkarinen, I. Takala, P. Mustajoki

Two year maintenance of weight loss after a VLCD and behavioural therapy for obesity: correlation to the scores of questionnaires measuring eating behaviour.
International Journal of Obesity 1996; 20:332-337

Helsinki University Hospital Finland
9
S. Rössner, H. Flaten

VLCD versus LCD in long-term treatment of obesity. International Journal of Obesity 1997; 21:22-26

Karolinska Hospital, Stockholm Sweden
10
G. M. Fogelholm, H. T. Sievänen,
W. D. van Marken Lichtenbelt, K. R. Westerterp

Assessment of Fat-Mass Loss During Weight Reduction in Obese Women. Metabolism 1997; 46:968-975

Institute for Health promotion Research, Finland
11
K.R. Ryttig, H. Flaten, S. Rössner

Long-term effects of a very low calorie diet in obesity treatment. A prospective, randomized, comparison between VLCD and a hypocaloric diet+behavior modification and their combination. International Journal of Obesity 1997; 21:574-579

MEDDOC Research Centre, Hørsholm Norway
12
L.H. Høie, E. Myking, E.C. Reine, D. Bruusgaard

Diet and exercise in addition to psychotherapy, in the treatment of patients suffering from eating disorders with obesity.
Eating Weight Disord. 1997; 2:207-210

Buskerud Central Hospital, Drammen Norway
13
S. Rössner

Intermittent vs continuous VLCD therapy in obesity treatment. International Journal of Obesity 1998; 22: 190-192

Huddinge Hospital Sweden
14
T. Pekkarinen, I. Takala, P. Mustajoki

Predictors of long-term weight reduction in obese patients after initial very-low-calorie diet.
Advances in Therapy 1999; 16:285-289

Helsinki University Hospital Finland
15
L. H. Høie, D. Bruusgaard

Predictors of long-term weight reduction in obese patients after initial very-low-calorie diet.
Advances in Therapy 1999; 16:285:289

University of Oslo Norway
16
T. Danielson, S. Rössner, A. Westin

Open randomized trial of intermittent very low energy diet together with nicotine gum for stopping smoking in women who gained weight in previous attempts to quit.
BMJ 1999; 319:490-493

Karolinska Hospital, Stockholm Sweden
17
B. Stenius-Aarniala, T. Poussa, J. Kvarnstrom, E. Gronlund,
M. Ylikahri, P. Mustajoki

Immediate and long-term effects of weight reduction in obese people with asthma: randomised controlled study.
BMJ 2000; 320:827-32

Helsinki University Hospital Finland
18
M. Fogelholm, K. Kukkonen-Harjula, A. Nenonen, M. Pasanen

Effects of walking training on weight maintenance after a very-low-energy diet in premenopausal obese women.
Arch Intern Med 2000; 160:2177-84

Tampere University Hospital + Helsinki University Sweden
19
DB Allison, G Gadbury, LG Schwartz, R Murugesan, JL Kraker,
S Heshka, KR Fontaine, SB Heymsfield

A novel soy-based meal replacement formula for weight loss among obese individuals: A randomized controlled clinical trial Europ.
Journal of Clinical Nutrition 2003;57, 514-522

University of Alabama, St.Luke’s + Roosvelt Hospital New York USA
20
H Harder, B.Dinesen, A Astrup

The effect of a rapid weight loss on lipid profile and glycemic control in obese type 2 diabetic patients.
Journal of Clinical Nutrition 2003;57, 514-522

Royal Veterinary + Agricultural University Norway
21
JW Anderson, L Hoie

Weight loss and lipid changes with low-energy diets : Comparative study of milk based versus soy-based liquid meal replacements
Journal of American College of Nutrition (2005) 24, 210-216

University of Kentucky USA
22
SB .Haugaard, A Vaag, C-E Høy, S Madsbad

Desaturation of skeletal muscle structural and depot lipids in obese individuals during a very-low-calorie diet intervention
Obesity (2007) 15,1:117-125

University of Copenhagen Denmark

CLINICAL PUBLICATIONS - HEART HEALTH + DIABETES

B HEART HEALTH + DIABETES institute location
1
K. Hermansen, M. Søndergaard, L.Hoie, M. Carstensen, B. Brock

Beneficial Effects of a Soy-Based Dietary Supplement on Lipid Levels and Cardiovascular Risk Markers in Type 2 Diabetic Subjects Diabetes Care 2001; 24: 228-233

Aarhus University Hospital Denmark
2
S. Tonstad, K. Smerud, L. Høie

A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins, and plasma total homocysteine in hypercholesterolemic subjects
Am. J. Clin. Nutrition (2002); 76: 78-84

National Public Health Institute, Helsinki Finland
3
P. Puska, V. Korpelainen, L. Høie, E. Skovlund, K. Smerud

Soy in hypercholesterolaemia: a double-blind, placebo-controlled trial Europ. J. Clin. Nutrition (2002); 56: 352-357

National Public Health Institute, Helsinki Finland
4
P. Puska, V. Korpelainen, L. Høie, E. Skovlund, T. Lahti, K. Smerud

Isolated soya protein with standardised levels of isoflavones, cotyledon soya fibres and soya phospholipids improves plasma lipids in hypercholesterolaemia: A double bind, placebo controlled trial.
British Journal of Nutrition (2004), 91, 393–401

University of Oslo Norway
5
P. Clausen, J. Lindhardsen, L. Høie, S. Stender

ITreatment with Abacor, a soy-based dietary supplement, further reduces plasma concentrations of total and low-density lipoprotein cholesterol in statin-treated hypercholesterolaemic patients
Innovative Food Science and Emerging Technologies 5-(2004) 377–383

Gentofte University Hospital Denmark
6
L.Hoie, E.Morgenstern, J.Gruenwald, H-J. Graubaum, R.Busch, H-J.Zunft

A double-blind, placebo controlled trial compares the cholesterol-lowering effects of two different soy protein preparations in hypercholesterolemic subjects. European Journal of Nutrition. 44 (2005) 2, 65-71

German Inst. of Human Nutrition + Potsdam University Germany
7
G. M. Fogelholm, H. T. Sievänen, W. D. van Marken Lichtenbelt, K. R. Westerterp

Lipid-Lowering Effect of 2 Dosages of a Soy Protein Supplement in Hypercholesterolemia.
Advances in Therapy 22-(2005) 175-186

Inst. of Medical Biometry Charite-University, Berlin Germany
8
Stig Eric Underbjerg Dyrskoh, Per Bendix Jeppersen, Michele Colombo,

Preventive effects of a soy-based diet supplemented with Stevioside on the development of the metabolic syndrome and type-2 diabetes in Zucker diabetic fatty rats. Metabolism clinical and experimental 54 (2005) 1181 – 1188

Aarhus University Hospital Denmark
9
K.Hermansen, B.Hansen, TR.Jacobsen, P.Clausen, M.Dalgaard, B.Dinesen, E.Pedersen, A.Astrup

Effects of soy supplementation on blood lipids and arterial function in hypercholesterolaemic subjects
European Journal of Clinical Nutrition 59 (2005),7: 843-850

Aarhus University Hospital Denmark
10
L.Hoie, A.Sjoholm, M.Gulstrand, H-J.Zunft, W.Leuder, H-J.Graubaum, J.Gruenwald

Ultra heat treatment destroys cholesterol-lowering effect of soy protein International Journal of Food Sciences and Nutrition 57 (2006):512-519

Karolinska Hospital, Stockholm + Potsdam University Sweden + Germany